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KMID : 0613820090190111553
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Journal of Life Science
2009 Volume.19 No. 11 p.1553 ~ p.1561
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Biological Activities and Chemical Characteristics of Monascus-Fermented Korean Red Ginseng
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Park Jin-Chul
Do Eun-Soo
Cha Jae-Young
Cho Young-Su
Lee Chi-Hyeong
Kang In-Ho
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Abstract
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This study investigated the biological activities and chemical characteristics of Monascus-fermented Korean red ginseng (MFRG). The comparative activities of water, ethanol, and methanol extracts from MFRGE and Korean red ginseng (RG) were tested in vitro of antioxidative models of linoleic acid peroxidation by thiocyanate and thiobarbituric acid (TBA) methods and DPPH (α,α’-diphenyl-β-picrylhydrazyl) radical scavenging activities. In addition, measurements of their bioactive total phenolic compounds and minerals, and extract yield, were obtained. The extract yield of each solvent extracted from MFRG and RG was aqueous by 6.58% and 5.83%, ethanol by 0.62% and 0.98%, and methanol by 1.27% and 3.04%, respectively. Total phenolic compounds were higher in all solvents extracted from MFRG than those from RG. Major mineral contents (ppm) of MFRG and RG were K by 16,936 and 22,386, Ca by 2,310 and 3,693, Mg by 2,703 and 2,647, respectively. The DPPH radical scavenging activities were higher in all solvents extracted from MFRG than those from RG, however, all these extracts exhibited a relatively low level of radical-scavenging activity compared to the butylated hydroxytoluene (BHT). In antioxidative activities determined by TBA method using linoleic acid peroxidation, 70% methanol extract from MFRG and RG showed the highest antioxidative activity at a concentration of 0.1%. These results may provide the basic data to understand the biological activities of bio-active materials derived from MFRG.
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KEYWORD
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Monascus-fermented Korean red ginseng(MFRG), Korean red ginseng(RG), antioxidation, DPPH, lipid peroxidation
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